The Worry About Clopidogrel “Nonresponsiveness”
نویسندگان
چکیده
منابع مشابه
Genetic causes of clopidogrel nonresponsiveness: which ones really count?
Clopidogrel decreases the morbidity and mortality associated with several cardiovascular diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system. This activation is a source of significant interindividual variability in clopidogrel responsiveness. Drug interactions with and genetic variation in CYP3A4, CYP3A5, a...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Interventions
سال: 2009
ISSN: 1936-8798
DOI: 10.1016/j.jcin.2009.09.005